[PDF] To Favor Survival Under Food Shortage, the Brain Disables Costly Memory | Semantic Scholar (2024)

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@article{Plaais2013ToFS, title={To Favor Survival Under Food Shortage, the Brain Disables Costly Memory}, author={Pierre-Yves Plaçais and Thomas Pr{\'e}at}, journal={Science}, year={2013}, volume={339}, pages={440 - 442}, url={https://api.semanticscholar.org/CorpusID:32348558}}
  • P. Plaçais, T. Préat
  • Published in Science 25 January 2013
  • Biology

The brain of Drosophila specifically disables the costly formation of aversive long-term memory (LTM) upon starvation, a physiological state required for appetitive LTM formation.

146 Citations

Highly Influential Citations

12

Background Citations

58

Methods Citations

2

Results Citations

2

146 Citations

Fasting Launches CRTC to Facilitate Long-Term Memory Formation in Drosophila
    Yukinori HiranoT. Masuda M. Saitoe

    Biology

    Science

  • 2013

It was found that fasting facilitated LTM formation in general; aversive L TM formation also occurred after single-cycle training when mild fasting was applied before training, and both fasting-dependent and spaced training–dependent LTM required protein synthesis and cyclic adenosine monophosphate response element–binding protein (CREB) activity.

  • 115
Appetitive Memory with Survival Benefit Is Robust Across Aging in Drosophila
    Ayako TonokiM. OgasawaraZhihua YuMotoyuki Itoh

    Biology

    The Journal of Neuroscience

  • 2020

It is shown in Drosophila melanogaster that aged flies of both sexes form robust appetitive memory conditioned with nutritious sugar, which has survival benefits for aged flies, and Aging changes the neural circuits including dopamine neurons and neuropeptide F-expressing neurons leading to the age-dependent impairment in memory with insufficient survival benefits and the preservation of the ability to form memory with survival benefits.

Reinforcement learning when your life depends on it: a neuro-economic theory of learning
    Jiamu JiangEmilie FoyardMark C. W. van Rossum

    Economics

    bioRxiv

  • 2024

Synaptic plasticity enables animals to adapt to their environment, but memory formation can consume a substantial amount of metabolic energy, potentially impairing survival. Hence, a neuro-economic

  • PDF
Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans
    S. SkoraF. MendeM. Zimmer

    Biology

    Cell reports

  • 2018
  • 68
  • PDF
Insulin signaling gates long-term memory formation in Drosophila larvae
    Melanie EschmentHanna R FranzNazli GüllüLuis G HölscherKo-Eun HuhAnnekathrin Widmann

    Biology

    bioRxiv

  • 2019

Drosophila larvae are equipped with the capacity to form a protein synthesis independent so-called larval anaesthesia resistant memory (lARM), which is consolidated in terms of being insensitive to cold-shock treatments and it is determined that the metabolic state acts as a binary switch between the formation of lARM and lLTM.

  • 1
  • Highly Influenced
  • PDF
Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory
    P. PlaçaisÉloïse de Tredern T. Préat

    Biology

    Nature Communications

  • 2017

It is shown that increased energy flux in the mushroom body, driven by a pair of input dopaminergic neurons, is a command for the formation of long-term memory in Drosophila.

  • 122
  • PDF
Insulin signaling represents a gating mechanism between different memory phases in Drosophila larvae
    Melanie EschmentHanna R FranzNazli GüllüLuis G HölscherKo-Eun HuhAnnekathrin Widmann

    Biology

    PLoS genetics

  • 2020

Motivated by the fact that LTM formation causes an increase in energy uptake in Drosophila adults, the idea of whether an energy surplus can induce the formation of LTM in the larval stage was tested, and increasing the metabolic state by feeding Drosophile larvae the disaccharide sucrose directly before aversive olfactory conditioning led to the Formation of a protein synthesis dependent longer lasting memory.

Hunger and memory; CRTC coordinates long-term memory with the physiological state, hunger
    Yukinori HiranoM. Saitoe

    Biology

  • 2013

The recent study that mild fasting facilitates long-term memory (LTM) formation in Drosophila showed data suggesting that reduced insulin signaling during fasting activates CRTC, thereby inducing fLTM formation, which provides the conceptual advance that flies adapt their mechanisms for LTM formation according to their internal condition, hunger state.

  • 11
  • PDF
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
    Bryon SilvaO. L. Mantha T. Préat

    Biology, Environmental Science

    Nature Metabolism

  • 2022

During starvation, neurons of the fly olfactory memory centre import and use ketone bodies as an energy substrate to sustain aversive memory formation and it is shown that the master energy sensor AMP-activated protein kinase regulates both lipid mobilization and KB export in cortex glia.

  • 53
  • PDF
The effect of food quality during growth on spatial memory consolidation in adult pigeons
    M. ScribaJ. GaspariniL. JacquinC. Mettke-HofmannN. RattenborgA. Roulin

    Agricultural and Food Sciences, Biology

    Journal of Experimental Biology

  • 2017

It is demonstrated that food quality during development has long-lasting effects on memory, with a moderate nutritional deficit improving spatial memory performance in a foraging context.

  • 3
  • PDF

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54 References

Fasting Launches CRTC to Facilitate Long-Term Memory Formation in Drosophila
    Yukinori HiranoT. Masuda M. Saitoe

    Biology

    Science

  • 2013

It was found that fasting facilitated LTM formation in general; aversive L TM formation also occurred after single-cycle training when mild fasting was applied before training, and both fasting-dependent and spaced training–dependent LTM required protein synthesis and cyclic adenosine monophosphate response element–binding protein (CREB) activity.

  • 115
Functional and evolutionary trade-offs co-occur between two consolidated memory phases in Drosophila melanogaster
    F. LagasseCéline MorenoT. PréatF. Mery

    Biology

    Proceedings of the Royal Society B: Biological…

  • 2012

It is found that flies selected specifically for improvement of one consolidated memory phase show reduced performance in the other memory phase, the first evidence of a symmetrical evolutionary trade-off between two memory phases for the same learning task.

  • 30
  • PDF
Dopamine Controls Persistence of Long-Term Memory Storage
    J. I. RossatoL. BevilaquaI. IzquierdoJ. MedinaM. Cammarota

    Biology, Medicine

    Science

  • 2009

The persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points.

  • 421
Parametric and genetic analysis of Drosophila appetitive long‐term memory and sugar motivation
    J. ColombLaure KaiserLaure KaiserM. ChabaudT. Préat

    Biology

    Genes, brain, and behavior

  • 2009

This work designed and tuned an apparatus that facilitates repeated discriminative conditioning by alternate presentations of two odours, one being associated with sugar, as well as a new paradigm to test sugar responsiveness (SR), and shows that both SR and short‐term memory (STM) scores increase with starvation length before conditioning.

  • 102
  • PDF
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila
    M. KrashesS. Waddell

    Biology

    The Journal of Neuroscience

  • 2008

It is shown that a single 2 min training session pairing odor with a more ethologically relevant sugar reinforcement forms long-term appetitive memory that lasts for days, suggesting that appetitive middle-term memory and LTM are mechanistically linked.

  • 248
  • PDF
Drosophila long-term memory formation involves regulation of cathepsin activity
    D. ComasF. PetitT. Préat

    Biology

    Nature

  • 2004

A Drosophila melanogaster mutant, crammer (cer), which shows a specific LTM defect is described, suggesting that Cer might have a role in glia and that the concentration of the Cer peptide is critical for LTM.

  • 87
A Cost of Long-Term Memory in Drosophila
    F. MeryT. Kawecki

    Biology

    Science

  • 2005

It is shown that flies induced to form long-term memory become more susceptible to extreme stress (such as desiccation), in contrast, induction of anesthesia-resistant memory had no detectable effect on Desiccation resistance.

  • 257
  • PDF
Stress effects on memory: An update and integration
    L. SchwabeM. JoëlsB. RoozendaalO. WolfM. Oitzl

    Psychology

  • 2012
  • 644
  • PDF
A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
    M. KrashesM. Krashes S. Waddell

    Biology

    Cell

  • 2009
  • 514
  • PDF
Serotonin–mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei-Tseng LeeHsuan-Wen Lin A. Chiang

    Biology

    Proceedings of the National Academy of Sciences

  • 2011

It is reported that ARM is specifically enhanced or inhibited in flies with elevated or reduced serotonin (5HT) levels, respectively, suggesting that 5HT and Radish protein act on the same pathway for ARM formation.

  • 130
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    [PDF] To Favor Survival Under Food Shortage, the Brain Disables Costly Memory | Semantic Scholar (2024)

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